drugset / Trial / NCT01215552
Study of the Inhibition of [11C]R-rolipram Binding to Brain Phosphodiesterase - 4 (PDE-4) by HT-0712
Non-randomizedSingle-groupOpen-labelBasic science
Summary
This Positron Emission Tomography (PET) imaging study is designed to explore the relationship between HT-0712 dose level and inhibition of brain phosphodiesterase-4 activity, in order to optimize the dosage regimens utilized in subsequent trials.
Timeline
- Start
- 2010-09
- Primary completion
- 2010-11
- Completion
- 2011-01
Outcome
Outcome not reported
Stopped: “The experimental design was not sufficient to answer the proposed questions. A new study design is now being considered.”
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | HT-0712 | Small molecule | 5 mg | Oral |
| Subject | HT-0712 | Small molecule | 25 mg | Oral |
Indications
No indication recorded.