drugset / Trial / NCT01217736
Direct Renin Inhibition and the Kidney
Non-randomizedCrossoverOpen-labelBasic science
Summary
The objective of the study is to determine the magnitude of the effect of direct renin inhibition by VTP-27999 on renal plasma flow and kidney function.
Timeline
- Start
- 2010-09
- Primary completion
- 2011-11
- Completion
- 2011-11
Publications
- Results Barkoudah E, Danser AHJ, van Thiel BS, Fisher NDL, Gregg R, Hollenberg NK. Journal of the American Society of Hypertension 9(4)
- Results Barkoudah E, van Thiel BS, Fisher ND, Gregg RA, Danser AH, Moukarbel GV, Hollenberg NK. Maximum renal responses to renin inhibition in healthy study participants: VTP-27999 versus aliskiren. J Hypertens. 2016 May;34(5):935-41. doi: 10.1097/HJH.0000000000000860.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Aliskiren | Small molecule | 300 mg | — |
| Subject | VTP-27999 | Small molecule | 75 mg | — |
| Subject | VTP-27999 | Small molecule | 150 mg | — |
| Subject | VTP-27999 | Small molecule | 300 mg | — |
| Subject | VTP-27999 | Small molecule | 600 mg | — |