Effect of Teriparatide, Vibration and the Combination on Bone Mass and Bone Architecture in Chronic Spinal Cord Injury

Phase 2 Completed 60 enrolled Thomas J. Schnitzer Congressionally Directed Medical Research Programs · collab Edward Hines Jr. VA Hospital · collab University of Illinois at Chicago · collab

RandomizedParallel-groupTriple-blindTreatment

Summary

Spinal cord injury (SCI) results in marked acute loss of bone. This study evaluates the effect of teriparatide (PTH) and the use of vibration as a form of mechanical stimulation on bone mass.

Timeline

Start: 2010-10
Primary completion: 2015-08
Completion: 2016-08

Publications

Haider IT, Lobos SM, Simonian N, Schnitzer TJ, Edwards WB. Bone fragility after spinal cord injury: reductions in stiffness and bone mineral at the distal femur and proximal tibia as a function of time. Osteoporos Int. 2018 Dec;29(12):2703-2715. doi: 10.1007/s00198-018-4733-0. Epub 2018 Oct 17.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Teriparatide	Protein / enzyme biologic	20 ug	—

Effect of Teriparatide, Vibration and the Combination on Bone Mass and Bone Architecture in Chronic Spinal Cord Injury

Summary

Timeline

Publications

Drugs

Indications