Curcumin to Prevent Complications After Elective Abdominal Aortic Aneurysm (AAA) Repair

Phase 2/3 Completed 606 enrolled London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's Canadian Institutes of Health Research (CIHR) · collab

RandomizedParallel-groupQuadruple-blindPrevention

Summary

The purpose of this program of research is to determine whether curcumin, a natural health product, can prevent acute kidney injury and other complications after elective AAA repair. If proven safe and effective, curcumin is an inexpensive intervention which can be readily applied to almost 50,000 AAA repairs performed worldwide each year. New knowledge about this intervention may also guide its use in other surgical and medical settings to prevent complications to the kidneys, heart and other organs.

Timeline

Start: 2011-11
Primary completion: 2014-11
Completion: 2016-08

Outcome

Missed primary endpoint

paper Neither curcumin nor placebo significantly affected any of the 4 biomarkers (p > 0.05 for all comparisons). PMID 30373740 ↗

Publications

Garg AX, Devereaux PJ, Hill A, Sood M, Aggarwal B, Dubois L, Hiremath S, Guzman R, Iyer V, James M, McArthur E, Moist L, Ouellet G, Parikh CR, Schumann V, Sharan S, Thiessen-Philbrook H, Tobe S, Wald R, Walsh M, Weir M, Pannu N; Curcumin AAA AKI Investigators. Oral curcumin in elective abdominal aortic aneurysm repair: a multicentre randomized controlled trial. CMAJ. 2018 Oct 29;190(43):E1273-E1280. doi: 10.1503/cmaj.180510.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Curcumin	Small molecule	2000 mg	Oral