Safety and Efficacy of Delayed Manipulation After Xiaflex Treatment in Subjects With Dupuytren's Contracture

Phase 4 Terminated 37 enrolled Indiana Hand to Shoulder Center Stony Brook University · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

The purpose of this study is to determine if of manipulation of digits following collagenase injection for treatment of Dupuytren's contracture is effected by the amount of time between injection and manipulation.

Timeline

Start: 2010-12
Primary completion: 2012-12
Completion: 2012-12

Outcome

Outcome not reported

Stopped (Enrollment): “difficulty enrolling additional patients”

Publications

Background Hurst LC, Badalamente MA, Hentz VR, Hotchkiss RN, Kaplan FT, Meals RA, Smith TM, Rodzvilla J; CORD I Study Group. Injectable collagenase clostridium histolyticum for Dupuytren's contracture. N Engl J Med. 2009 Sep 3;361(10):968-79. doi: 10.1056/NEJMoa0810866.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Collagenase Clostridium Histolyticum	Protein / enzyme biologic	—	—