Heart Rate Control With Esmolol in Septic Shock

Summary

The purpose of this study is investigate the effects on systemic hemodynamics and organ function of esmolol when used to maintain heart rate below a predefined threshold in patients with septic shock.

Timeline

Start

2010-12

Primary completion

2012-07

Completion

2012-07

Outcome

Met primary endpoint

paper Targeted heart rates were achieved in all patients in the esmolol group compared with those in the control group. PMID 24108526 ↗

Publications

• Huang X, Zheng M, Zhu Z, Zhang Y, Chen KY. Association of anti-catecholaminergic antiarrhythmic drugs with survival in sepsis-associated new-onset atrial fibrillation. Sci Rep. 2026 Jul 6;16(1):20588. doi: 10.1038/s41598-026-51249-9.
• Morelli A, Ertmer C, Westphal M, Rehberg S, Kampmeier T, Ligges S, Orecchioni A, D'Egidio A, D'Ippoliti F, Raffone C, Venditti M, Guarracino F, Girardis M, Tritapepe L, Pietropaoli P, Mebazaa A, Singer M. Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock: a randomized clinical trial. JAMA. 2013 Oct 23;310(16):1683-91. doi: 10.1001/jama.2013.278477.

Drugs

Indications