Atypical Antipsychotic Treatment Effect On Brain Function In Schizophrenia Measured By FMRI

Summary

The general aim is to compare the effects of typical and atypical antipsychotic medication on brain structure and function. A parallel group treatment trial will be utilized to compare the effects of the typical antipsychotic thiothixene versus the atypical antipsychotics risperidone (RIS) and olanzapine (OLZ) on brain structure and function in schizophrenia in an effort to determine the neuroanatomic basis for cognitive pathology in schizophrenia and its amelioration by atypical antipsychotic drugs.

Timeline

Start

2002-01

Primary completion

2005-06

Completion

2007-12

Drugs

Indications