Development of A Technique to Predict Antidepressant Responsiveness in Depressive Patients

Summary

First, the investigators examined the functional relevance of serotonin transporter polymorphisms by quantifying the activity of serotonin transporter in blood platelets of genotyped healthy volunteers and patients with major depression. Second, the investigators studied response to SSRIs in relation to 5-HTTLPR genotype and also to the functional expression of 5-HTT in platelets.

Timeline

Start

1999-10

Primary completion

2003-12

Completion

2016-12

Drugs

Indications