Islet Transplantation in Type 1 Diabetic Kidney Allograft

Summary

The purpose of this study is to learn about the safety of islet transplantation when performed after kidney transplantation, which may provide more normal control of blood sugar without the need for insulin shots. Islets are special clusters of cells within the pancreas that produce insulin. These cells will be obtained from cadaver (non-living) donors and given to subjects by vein.

Timeline

Start

2010-12

Primary completion

2026-12

Completion

2026-12

Publications

• Background Pathak P, Thampy R, Schat R, Bellin M, Beilman G, Hosseini N, Spilseth B. Transplantation for type 1 diabetes: radiologist's primer on islet, pancreas and pancreas-kidney transplantation imaging. Abdom Radiol (NY). 2024 Oct;49(10):3637-3665. doi: 10.1007/s00261-024-04368-8. Epub 2024 May 28.
• Background Gariani K, Peloso A, Galani V, Haidar F, Wassmer CH, Kumar R, Lacin EH, Olivier V, Prada P, Compagnon P, Berishvili E, Berney T. Effect of islet alone or islets after kidney transplantation on quality of life in type 1 diabetes: A systematic review. Transplant Rev (Orlando). 2024 Dec;38(4):100870. doi: 10.1016/j.trre.2024.100870. Epub 2024 Jun 21.

Drugs

Indications