In Vivo Assessment of Silver Biomaterial Nano-Toxicity

Phase 1/2 Completed 36 enrolled University of Utah

RandomizedCrossoverDouble-blind

Summary

Nanotechnology is the controlled generation and manipulation of matter in dimensions less than 100 nm. Silver has been used for its bactericidal properties. The investigators propose to study the American Biotech Laboratory 32 ppm silver solution over a 14-day period in human volunteers to determine the toxicity and to quantify cytochrome P450 enzyme effects of this solution.

Timeline

Start: 2010-12
Primary completion: 2011-07
Completion: 2011-07

Publications

Munger MA, Radwanski P, Hadlock GC, Stoddard G, Shaaban A, Falconer J, Grainger DW, Deering-Rice CE. In vivo human time-exposure study of orally dosed commercial silver nanoparticles. Nanomedicine. 2014 Jan;10(1):1-9. doi: 10.1016/j.nano.2013.06.010. Epub 2013 Jun 28.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Silver nanoparticles	Unknown	10 ppm	Oral
Subject	Silver nanoparticles	Unknown	32 ppm	Oral

Indications

No indication recorded.