drugset / Trial / NCT01248273

Unimolecular Pentavalent (Globo-H-GM2-sTn-TF-Tn) Immunization of Patients With Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer in First Remission

NCT01248273

Phase 1 Completed 26 enrolled Memorial Sloan Kettering Cancer Center
NaSingle-groupOpen-labelTreatment

Summary

The purpose of this study is to 1) test the safety of the vaccine to find out what effects, good and/or bad, it has, and 2) to find out if the vaccine stimulates the immune system. The vaccine in this study will contain several parts. The first part is called an antigen. These antigens or "fingerprints" are found on many cancer cells, especially from the ovaries, fallopian tubes, or peritoneal cavity (inside lining of the abdomen) The purpose of this study is to see if investigators can help the immune system to recognize that cancer cells are not normal and should be removed.

Timeline

Start
2010-11
Primary completion
2017-03
Completion
2017-03

Drugs

EvaluationDrugModalityDoseRoute
Subject Globo-H-GM2-sTn-TF-Tn-KLH conjugate Vaccine 25 ug Subcutaneous
Subject Globo-H-GM2-sTn-TF-Tn-KLH conjugate Vaccine 50 ug Subcutaneous
Subject Globo-H-GM2-sTn-TF-Tn-KLH conjugate Vaccine 100 ug Subcutaneous
Background QS-21 Other / unclassified Subcutaneous