drugset / Trial / NCT01248338
Effects of Nebivolol Versus Metoprolol Succinate on Endothelial Function
RandomizedParallel-groupQuadruple-blindTreatment
Summary
An impairment of endothelial function plays the central role in the pathogenesis of cardiovascular diseases and their complications. Most of cardiovascular risk factors are known to impair endothelial function and the established disease further aggravates endothelial dysfunction. The aim of the present study is to investigate the effects of nebivolol or metoprolol succinate on endothelial function and large artery stiffness.
Timeline
- Start
- 2006-03
- Primary completion
- 2008-12
- Completion
- 2009-12
Publications
- Serg M, Kampus P, Kals J, Zagura M, Zilmer M, Zilmer K, Kullisaar T, Eha J. Nebivolol and metoprolol: long-term effects on inflammation and oxidative stress in essential hypertension. Scand J Clin Lab Invest. 2012 Sep;72(5):427-32. doi: 10.3109/00365513.2012.691991. Epub 2012 Jun 18.
- Kampus P, Serg M, Kals J, Zagura M, Muda P, Karu K, Zilmer M, Eha J. Differential effects of nebivolol and metoprolol on central aortic pressure and left ventricular wall thickness. Hypertension. 2011 Jun;57(6):1122-8. doi: 10.1161/HYPERTENSIONAHA.110.155507. Epub 2011 May 2.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Metoprolol | Other / unclassified | 50 mg | Oral |
| Comparator | Metoprolol | Other / unclassified | 100 mg | Oral |
| Subject | Nebivolol | Other / unclassified | 5 mg | — |