To Assess the Efficacy of Esomeprazole 40 mg Once Daily in Subjects Who Still Had Heartburn After Receiving Rabeprazole

Summary

Administration of esomeprazole 40 mg to subjects who still had heartburn after receiving rabeprazole 20 mg once daily for 4 to 8 weeks will result in statistically significant improvement of heartburn after 8-week treatment.

Timeline

Start

2010-11

Primary completion

2011-06

Completion

2011-06

Outcome

Met primary endpoint

registry MEAN Arm 1 - Esomeprazole 40 mg: -3.3 (Standard Deviation 2.36) Number of days NCT01249651 ↗

registry p <0.001; Wilocoxon signed-rank test NCT01249651 ↗

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Esomeprazole	Small molecule	40 mg	—

Indications