Effects of 'Seroquel-XR' on the Improvement of Neurocognitive Function in People At-risk Mental States(ARMS)

Summary

The primary objective of this study is to assess the effects of 'Seroquel-XR' on the verbal learning ability in people with at-risk mental state (ARMS) over a 12 week period. The verbal learning ability will be indexed by delayed free recall score of CVLT(California Verbal learning Test), a standard neuropsychological verbal memory tests. The secondary objective is to assess the effects of 'Seroquel-XR' on other cognitive function and psychiatric symptoms including psychotic, anhedonic symptoms, and impulsivity. The cognitive function abilities will be measured by standard neuropsychological tests as follows; * Working memory: verbal \& spatial 2-back test * Attention: Digit Span, 3-7 CPT(Continuous Performance Test) * Executive function: WCST (Wisconsin Card Sorting Test) * Visuo-spatial ability: Rey Complex Figure Task copy * Visuomotor speed and planning: Trail making test A \& B * Verbal fluency: Controlled Oral Word Association Test(COWAT) The scales of psychiatric symptoms which will be used are as follows; * Psychotic symptoms: Scales of Prodromal scales (SOPS), Positive and negative syndrome scale (PANSS) * Anhedonia: Social Anhedonia Scale (SAS), Physical Anhedonia Scale (PAS) * Social cognition: Ambiguous Intention Hostility Questionnaire (AIHQ) * Impulsivity: Barrett Impulsivity Scale (BIS)

Timeline

Start

2010-11

Primary completion

2011-10

Completion

2012-10

Drugs

Indications