Mechanisms of Improvement With Beta-Blocker Treatment in Heart Failure

Summary

The overall hypothesis of this application is that the improvement in LV ejection performance following treatment with betablockers is due, at least in part, to improvement in intrinsic myocardial contractility.

Timeline

Start

2001-12

Primary completion

2005-10

Completion

2005-10

Publications

• Background Bozkurt B, Bolos M, Deswal A, Ather S, Chan W, Mann DL, Carabello B. New insights into mechanisms of action of carvedilol treatment in chronic heart failure patients--a matter of time for contractility. J Card Fail. 2012 Mar;18(3):183-93. doi: 10.1016/j.cardfail.2011.11.004. Epub 2011 Dec 22.

Drugs

Indications