drugset / Trial / NCT01265069

Efficacy of 10-day Concomitant Regimen Versus High Dose Dual Therapy in Anti-Helicobacter Pylori Rescue Therapy

NCT01265069

RandomizedParallel-groupOpen-labelTreatment

Summary

Currently, a 10-day concomitant therapy has been reported to be equally effective and safe to the 10-day sequential therapy for 1st-line anti-Helicobacter pylori(H. pylori) therapy. To our knowledge, there has been no report concerning the efficacy of this regimen used as a rescue therapy. The aims of this study are: 1. to compare the efficacy of high dose dual therapy and concomitant therapy as rescue regimen in H. pylori eradication; 2. to compare the patient adherence and adverse effects of these treatment regimens; 3. to investigate factors that may influence H. pylori eradication by these treatment regimens.

Timeline

Start
2010-11
Primary completion
2013-06
Completion
2013-12

Drugs

EvaluationDrugModalityDoseRoute
Subject Amoxicillin Other / unclassified 750 mg
Subject Amoxicillin Other / unclassified 1000 mg
Subject Clarithromycin Small molecule 500 mg
Subject Metronidazole Small molecule 500 mg
Subject Rabeprazole Small molecule 20 mg