24-hour IOP-lowering Effect of 0.01% Bimatoprost

Phase 4 Completed 16 enrolled University of California, San Diego

NaSingle-groupOpen-labelTreatment

Summary

This study will evaluate the 24-hour IOP-lowering efficacy of 0.01% bimatoprost once daily in patients with glaucoma or ocular hypertension

Timeline

Start: 2011-01
Primary completion: 2012-10
Completion: 2012-10

Outcome

Met primary endpoint

paper The diurnal and nocturnal IOP means were significantly lower under the bimatoprost 0.01% treatment than baseline in both the sitting and supine positions. PMID 22918671 ↗

paper The diurnal and nocturnal OPP means were significantly higher under treatment than baseline in both the sitting and supine positions. PMID 22918671 ↗

Publications

Results Tung JD, Tafreshi A, Weinreb RN, Slight JR, Medeiros FA, Liu JH. Twenty-four-hour effects of bimatoprost 0.01% monotherapy on intraocular pressure and ocular perfusion pressure. BMJ Open. 2012 Aug 23;2(4):e001106. doi: 10.1136/bmjopen-2012-001106. Print 2012.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Bimatoprost	Other / unclassified	0.01 %	—