Symptomatic Relief of Acute Dyspeptic Pain in Emergency Department With Pantoprazole

Summary

The purpose of this study is to evaluate the immediate synergistic effect on the relief of severe acid-related dyspeptic pain by adding intravenous pantoprazole to the combination of oral antacid and antispasmodic agent (the conventional treatment).

Timeline

Start

2011-01

Primary completion

2011-10

Completion

2011-10

Outcome

Missed primary endpoint

registry analysis (superiority or other test); Conventional vs Pantoprazole; p = 0.6; Mean Difference (Final Values) -2.6 (95% CI -12.7 to 7.4); t-test, 2 sided NCT01281501 ↗

paper There was no difference in the mean 60-minute visual analog scale scores between the treatment groups. PMID 22463973 ↗

Publications

• Results Musikatavorn K, Tansangngam P, Lumlertgul S, Komindr A. A randomized controlled trial of adding intravenous pantoprazole to conventional treatment for the immediate relief of dyspeptic pain. Am J Emerg Med. 2012 Nov;30(9):1737-42. doi: 10.1016/j.ajem.2012.02.001. Epub 2012 Mar 29.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Pantoprazole	Other / unclassified	80 mg	Intravenous
Background	Aluminum hydroxide	Unknown	1.32 g	Oral
Background	Hyoscine butylbromide	Unknown	20 mg	Intravenous
Background	magnesium hydroxide	Unknown	0.72 g	Oral

Indications