Risperidone vs. Olanzapine as add-on Treatment in Treatment Resistant Depression

Summary

Atypical neuroleptics may have antidepressant qualities in bipolar depression and in unipolar depression. Some data support the use of both Risperidone and Olanzapine, but there are no direct comparisons of their relative efficacy and tolerability in treatment resistant depression. The current study was designed as a pilot study to examine efficacy and tolerability of Olanzapine vs. Risperidone add on to a failed serotonin re-uptake inhibitor (SSRI) in depression.

Timeline

Start

2002-08

Primary completion

2004-03

Completion

2004-03

Drugs

Indications