Comparison of Retinol 1.0% and Tretinoin 0.02% in the Treatment of Moderate to Severe Photodamage and Wrinkles

Phase 2 Completed 24 enrolled Johns Hopkins University

RandomizedParallel-groupTriple-blindTreatment

Summary

The purpose of this study is to assess the comparative efficacy of retinol 1.0% and tretinoin 0.02% in minimizing wrinkles, discoloration, roughness, and other signs of moderate to severe photodamage. Our hypothesis is that both products will be of comparable benefit.

Timeline

Start: 2010-11
Primary completion: 2011-12
Completion: 2011-12

Publications

Chien AL, Kim DJ, Cheng N, Shin J, Leung SG, Nelson AM, Zang J, Suh H, Rainer B, Wallis L, Okoye GA, Loss M, Kang S. Biomarkers of Tretinoin Precursors and Tretinoin Efficacy in Patients With Moderate to Severe Facial Photodamage: A Randomized Clinical Trial. JAMA Dermatol. 2022 Aug 1;158(8):879-886. doi: 10.1001/jamadermatol.2022.1891.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Retinol	Unknown	1 %	Topical
Comparator	Tretinoin	Small molecule	0.02 %	Topical

Indications

No indication recorded.