Chamomile for Chronic Primary Insomnia

Summary

The purpose of this study is to determine if an herb called chamomile can help to treat insomnia (difficulty in going to sleep or getting enough sleep) by increasing the amount of time that you sleep and/or improving the quality of your sleep. The study will also be looking at the effect of chamomile on day time fatigue and functioning.

Timeline

Start

2008-07

Primary completion

2010-12

Completion

2010-12

Outcome

Missed primary endpoint

registry analysis (superiority test); Placebo Tablet vs Chamomile High Grade Extract; p = 0.21; t-test, 2 sided NCT01286324 ↗

paper There were no significant differences between groups in changes in sleep diary measures PMID 21939549 ↗

Publications

• Results Zick SM, Wright BD, Sen A, Arnedt JT. Preliminary examination of the efficacy and safety of a standardized chamomile extract for chronic primary insomnia: a randomized placebo-controlled pilot study. BMC Complement Altern Med. 2011 Sep 22;11:78. doi: 10.1186/1472-6882-11-78.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Chamomile High Grade Extract	Traditional medicine (herbal / TCM)	270 mg	Oral

Indications