drugset / Trial / NCT01290055
Turnover of Antigen Specific Lymphocytes and Monocytes After Immunization With the 17D Yellow Fever Vaccine
Phase 4
Completed
27 enrolled
Sri Edupuganti
National Institute of Allergy and Infectious Diseases (NIAID) · collabNational Institutes of Health (NIH) · collabUniversity of California, Berkeley · collab
Non-randomizedSequentialOpen-labelBasic science
Summary
The yellow fever vaccine is a live, attenuated virus that results in a robust immune response, especially in the T cell compartment. The researchers have been studying immune responses to live viral infections using the yellow fever vaccine as a model for a live viral infection. In this study, the researchers are interested in looking at the processing and lifespan of yellow fever specific CD8 T cell by measuring DNA replication and cell proliferation in humans using a naturally occurring stable isotope called deuterium.
Timeline
- Start
- 2019-04-15
- Primary completion
- 2024-10-25
- Completion
- 2024-10-25
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | YFV-17D | Vaccine | — | — |