Incidence of Hyponatremia in PEG-SD Compared to PEG-ELS

Completed 460 enrolled Thomas Jefferson University Bausch Health Americas, Inc. · collab

RandomizedParallel-groupSingle-blind

Summary

Objective: To compare the incidence of peri-colonoscopy hyponatremia associated with PEG 3350 + sports drink (PEG-SD) versus PEG 3350-electrolyte solution + sodium sulfate + sodium ascorbate and ascorbic acid (PEG-ELS). Hypothesis: As compared to PEG-SD, hyponatremia occurs significantly less often with PEG-ELS.

Timeline

Start: 2010-06
Primary completion: 2012-05
Completion: 2012-09

Publications

Matro R, Daskalakis C, Negoianu D, Katz L, Henry C, Share M, Kastenberg D. Randomised clinical trial: Polyethylene glycol 3350 with sports drink vs. polyethylene glycol with electrolyte solution as purgatives for colonoscopy--the incidence of hyponatraemia. Aliment Pharmacol Ther. 2014 Sep;40(6):610-9. doi: 10.1111/apt.12884. Epub 2014 Jul 28.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	PEG-ELS	Unknown	—	—
Subject	polyethylene glycol	Other / unclassified	119 g	—
Background	Bisacodyl	Small molecule	10 mg	—

Indications

No indication recorded.