The Relationship Between Body Composition and Growth Hormone, SIRT Signaling, Protein Turnover and Insulin Sensitivity

Completed 19 enrolled University of Aarhus Aarhus University Hospital · collab

RandomizedCrossoverOpen-labelBasic science

Summary

The purpose of this study is to investigate signaling pathways in fat and muscle, as well as turnover of protein, sugar and fat after stimulation with growth hormone and during fasting in lean and obese subjects. This will help clarify differences in the human metabolism between lean and obese subject and provide us with a better understanding of the molecular mechanisms regulating the basic metabolism during prolonged fasting.

Timeline

Start: 2011-01
Primary completion: 2013-12
Completion: 2013-12

Publications

Hogild ML, Bak AM, Pedersen SB, Rungby J, Frystyk J, Moller N, Jessen N, Jorgensen JOL. Growth hormone signaling and action in obese versus lean human subjects. Am J Physiol Endocrinol Metab. 2019 Feb 1;316(2):E333-E344. doi: 10.1152/ajpendo.00431.2018. Epub 2018 Dec 21.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Acipimox	Small molecule	250 mg	—
Subject	Somatropin	Protein / enzyme biologic	0.005 mg/kg	Intravenous

Indications

No indication recorded.