drugset
drugset / Trial / NCT01312350

Neoadjuvant Chemotherapy for Locally Advanced Squamous Cell Cancer of the Head and Neck (SCCHN)

NCT01312350 ↗

Phase 2 Completed 40 enrolled Samsung Medical Center
RandomizedParallel-groupOpen-labelTreatment

Summary

The investigators will examine whether 2-cycles of DFP chemotherapy before definitive concurrent chemoradiation therapy (CCRT) can improve progression-free survival in locally advanced (Stage III \& IVM0) hypopharyngeal and base of tongue carcinoma compared to definitive CCRT alone.

Timeline

Start
2010-11
Primary completion
2016-03
Completion
2018-12

Drugs

EvaluationDrugModalityDoseRoute
Subject Cisplatin Other / unclassified 75 mg/m2 —
Subject Cisplatin Other / unclassified 100 mg/m2 —
Subject Docetaxel Small molecule 75 mg/m2 —
Subject fluorouracil Small molecule 759 mg/m2 —

Indications

hypopharyngeal carcinoma