drugset / Trial / NCT01313143
A Short Term Pharmacokinetic, Pharmacodynamic and Tolerability Study to Compare AOP200704 vs. Esmolol
RandomizedCrossoverTriple-blindTreatment
Summary
Pharmacokinetics, pharmacodynamics and tolerability of AOP200704 infusion is compared to that of Esmolol by measurement of plasma concentrations of AOP200704, esmolol and their metabolites, by assessing the effect of both drugs on dobutamine-induced tachycardia, and by monitoring vital signs, ECG and adverse events.
Timeline
- Start
- 2011-03
- Primary completion
- 2011-05
- Completion
- 2012-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Esmolol | Other / unclassified | — | Other |
| Subject | Landiolol | Small molecule | — | Other |
Indications
No indication recorded.