drugset / Trial / NCT01314898
A Single Dose Study Of Antimineralocorticoid Activity Of PF-03882845 In Healthy Volunteers
RandomizedCrossoverDouble-blindTreatment
Summary
24-hr urinary sodium/potassium ratio will be a sensitive biomarker of antimineralocorticoid activity. The dose-response relationship of the antimineralocorticoid activity of PF-03882845 can be established following single oral doses.
Timeline
- Start
- 2011-03
- Primary completion
- 2011-06
- Completion
- 2011-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | PF-03882845 | Small molecule | 3 mg | Oral |
| Subject | PF-03882845 | Small molecule | 10 mg | Oral |
| Subject | PF-03882845 | Small molecule | 30 mg | Oral |
| Subject | PF-03882845 | Small molecule | 100 mg | Oral |
| Subject | Spironolactone | Small molecule | 100 mg | Oral |
Indications
No indication recorded.