Ibudilast in the Treatment of Medication Overuse Headache

Phase 1/2 Unknown 40 enrolled University of Adelaide University of South Australia · collab

RandomizedParallel-groupDouble-blindTreatment

Summary

The purpose of this study is to determine if ibudilast is effective in reverting patients with medication overuse headache suffering chronic daily headache back to their original episodic headache pattern.

Timeline

Start: 2011-04
Primary completion: 2013-06
Completion: 2013-08

Publications

Background Bigal ME, Lipton RB. Excessive acute migraine medication use and migraine progression. Neurology. 2008 Nov 25;71(22):1821-8. doi: 10.1212/01.wnl.0000335946.53860.1d.
Background Obermann M, Katsarava Z. Management of medication-overuse headache. Expert Rev Neurother. 2007 Sep;7(9):1145-55. doi: 10.1586/14737175.7.9.1145.
Background Hutchinson MR, Bland ST, Johnson KW, Rice KC, Maier SF, Watkins LR. Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward. ScientificWorldJournal. 2007 Nov 2;7:98-111. doi: 10.1100/tsw.2007.230.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ibudilast	Small molecule	40 mg	Oral

Indications

No indication recorded.