Abuse Potential of Sativex

Phase 1 Completed 58 enrolled Jazz Pharmaceuticals

RandomizedCrossoverQuadruple-blindBasic science

Summary

This crossover study with six treatment sessions is to evaluate the abuse potential of three doses of Sativex as compared to Marinol and placebo, in subjects with a history of recreational marijuana use.

Timeline

Start: 2008-02
Primary completion: 2008-06
Completion: 2008-06

Publications

Results Schoedel KA, Chen N, Hilliard A, White L, Stott C, Russo E, Wright S, Guy G, Romach MK, Sellers EM. A randomized, double-blind, placebo-controlled, crossover study to evaluate the subjective abuse potential and cognitive effects of nabiximols oromucosal spray in subjects with a history of recreational cannabis use. Hum Psychopharmacol. 2011 Apr;26(3):224-36. doi: 10.1002/hup.1196.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Dronabinol	Other / unclassified	20 mg	—
Comparator	Dronabinol	Other / unclassified	40 mg	—
Subject	Nabiximols	Other / unclassified	10.8 mg	Other
Subject	Nabiximols	Other / unclassified	21.6 mg	Other
Subject	Nabiximols	Other / unclassified	43.2 mg	Other

Indications

No indication recorded.