drugset / Trial / NCT01337674
Co-Administration of MK-4618 With Antihypertensive Agents (MK-4618-010)
RandomizedCrossoverDouble-blindTreatment
Summary
This study will evaluate the safety and tolerability of MK-4618 when coadministered with antihypertensive agents and will evaluate changes in blood pressure following co-administration of MK-4618 with a beta blocker and a vasodilator. The primary hypothesis of the study is that MK-4618 does not result in a clinically meaningful change in systolic blood pressure relative to placebo when co-administered with a beta-blocker or with amlodipine.
Timeline
- Start
- 2011-04-01
- Primary completion
- 2011-11-01
- Completion
- 2011-11-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Vibegron | Unknown | 100 mg | Oral |
| Background | Amlodipine | Other / unclassified | — | — |
| Background | Metoprolol | Other / unclassified | — | — |