drugset / Trial / NCT01337674

Co-Administration of MK-4618 With Antihypertensive Agents (MK-4618-010)

NCT01337674

Phase 1 Completed 26 enrolled Merck Sharp & Dohme LLC
RandomizedCrossoverDouble-blindTreatment

Summary

This study will evaluate the safety and tolerability of MK-4618 when coadministered with antihypertensive agents and will evaluate changes in blood pressure following co-administration of MK-4618 with a beta blocker and a vasodilator. The primary hypothesis of the study is that MK-4618 does not result in a clinically meaningful change in systolic blood pressure relative to placebo when co-administered with a beta-blocker or with amlodipine.

Timeline

Start
2011-04-01
Primary completion
2011-11-01
Completion
2011-11-01

Drugs

EvaluationDrugModalityDoseRoute
Subject Vibegron Unknown 100 mg Oral
Background Amlodipine Other / unclassified
Background Metoprolol Other / unclassified

Indications