The Effect of Ketamine on Production of Inflammatory Markers in Post Operative Patients in Mulago Hospital

Phase 4 Unknown 30 enrolled Makerere University

RandomizedParallel-groupTriple-blind

Summary

. Null Hypothesis: Giving low doze ketamine (0.5mg/kg) given preoperatively to adult patients undergoing elective surgery, in Mulago hospital, will not have a reduction effect on the levels of IL-6 \& IL-1β pro inflammatory markers by 48 hours. . Alternate Hypothesis: Giving low doze ketamine (0.5mg/kg) given preoperatively to adult patients undergoing elective surgery, in Mulago hospital, will have a reduction effect on the levels of IL-6 \& IL-1β pro inflammatory markers by 48 hours.

Timeline

Start: 2011-04
Primary completion: 2011-05
Completion: 2011-06

Publications

Luggya TS, Roche T, Ssemogerere L, Kintu A, Kasumba JM, Kwizera A, Tindimwebwa JV. Effect of low-dose ketamine on post-operative serum IL-6 production among elective surgical patients: a randomized clinical trial. Afr Health Sci. 2017 Jun;17(2):500-507. doi: 10.4314/ahs.v17i2.25.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Ketamine	Small molecule	0.5 mg/kg	Intravenous

Indications

No indication recorded.