drugset / Trial / NCT01340456
Cholesterol Metabolites as Markers for CYP3A Induction
RandomizedParallel-groupOpen-labelDiagnostic
Summary
The objectives of this study are: * To investigate if the endogenous cholesterol metabolite, 4beta-OHcholesterol could be used as a marker for induction of cytochrome P450 (CYP) 3A4. * To compare 4beta-OHcholesterol with midazolam as a marker for induction of CYP3A4.
Timeline
- Start
- 2011-05
- Primary completion
- 2011-07
- Completion
- 2011-07
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Rifampin | Small molecule | 10 mg | — |
| Subject | Rifampin | Small molecule | 20 mg | — |
| Subject | Rifampin | Small molecule | 100 mg | — |
Indications
No indication recorded.