Effects of LDX on Functioning of College Students With ADHD

Summary

The purpose of this study was to evaluate the effects of lisdexamfetamine dimesylate, a prodrug stimulant, on the behavioral, academic, and psychosocial functioning of college students with attention-deficit/hyperactivity disorder (ADHD). Twenty-five college students with ADHD from two universities (University of Rhode Island and Lehigh University) completed a within-subject, placebo-controlled research trial. Dependent measures tapping behavioral, psychosocial, and academic functioning were completed on a weekly basis across five conditions (baseline, placebo, and 30-mg, 50-mg, and 70-mg lisdexamfetamine).

Timeline

Start

2009-09

Primary completion

2010-12

Completion

2010-12

Outcome

Met primary endpoint

registry analysis (unspecified test); Placebo vs LDX 30-mg vs LDX 50-mg vs LDX 70-mg; p <0.001; Partial eta squared .34; ANOVA NCT01342445 ↗

registry analysis (unspecified test); Placebo vs LDX 30-mg vs LDX 50-mg vs LDX 70-mg; p <.001; partial eta squared 0.28; ANOVA NCT01342445 ↗

Publications

• Results Dupaul GJ, Weyandt LL, Rossi JS, Vilardo BA, O'Dell SM, Carson KM, Verdi G, Swentosky A. Double-blind, placebo-controlled, crossover study of the efficacy and safety of lisdexamfetamine dimesylate in college students with ADHD. J Atten Disord. 2012 Apr;16(3):202-20. doi: 10.1177/1087054711427299. Epub 2011 Dec 12.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Lisdexamfetamine	Other / unclassified	30 mg	—
Subject	Lisdexamfetamine	Other / unclassified	50 mg	—
Subject	Lisdexamfetamine	Other / unclassified	70 mg	—

Indications