Lovastatin and Its ß-hydroxy Acid From Four 600 mg LipoCol Forte® Capsules Compared to That of One 20 mg Mevacor® Tablet in Healthy Subjects

Phase 4 Completed 14 enrolled Taipei Medical University WanFang Hospital

RandomizedCrossoverOpen-labelTreatment

Summary

The objective of the study is to evaluate the relative bioavailability of lovastatin and its ß-hydroxy acid of 600 mg LipoCol Forte® Capsules compared to that of one 20 mg Mevacor® Tablet after single oral administration in healthy subjects using a 2x2 crossover design.

Timeline

Start: 2006-10
Primary completion: 2006-10
Completion: 2006-10

Publications

Chen CH, Yang JC, Uang YS, Lin CJ. Improved dissolution rate and oral bioavailability of lovastatin in red yeast rice products. Int J Pharm. 2013 Feb 28;444(1-2):18-24. doi: 10.1016/j.ijpharm.2013.01.028. Epub 2013 Jan 23.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	LipoCol	Unknown	2400 mg	Oral
Subject	Lovastatin	Small molecule	20 mg	Oral

Indications

No indication recorded.