Radiation Therapy and Intratumoral Autologous Dendritic Cells in Soft Tissue Sarcomas (STS)

Phase 2 Completed 20 enrolled H. Lee Moffitt Cancer Center and Research Institute University of Florida · collab

Non-randomizedParallel-groupOpen-labelTreatment

Summary

The purpose of this study is to determine if injection of the participant's our own immune related white blood cells (called dendritic cells) into their tumor will strengthen their immune system to fight against their cancer.

Timeline

Start: 2011-01
Primary completion: 2013-08
Completion: 2016-04

Publications

Hong WX, Sagiv-Barfi I, Czerwinski DK, Sallets A, Levy R. Neoadjuvant Intratumoral Immunotherapy with TLR9 Activation and Anti-OX40 Antibody Eradicates Metastatic Cancer. Cancer Res. 2022 Apr 1;82(7):1396-1408. doi: 10.1158/0008-5472.CAN-21-1382.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	autologous dendritic cells	Cell therapy	—	Other

Radiation Therapy and Intratumoral Autologous Dendritic Cells in Soft Tissue Sarcomas (STS)

Summary

Timeline

Publications

Drugs

Indications