EXPAREL Dose-Response for Single-Injection Femoral Nerve Blocks

Phase 1 Completed 14 enrolled University of California, San Diego Pacira Pharmaceuticals, Inc · collab

NaSingle-groupDouble-blindTreatment

Summary

EXPAREL™, an investigational drug product, is a new formulation of a local anesthetic (numbing medicine) that is designed to be longer acting than the currently-available local anesthetics. The purpose of this study is to define the dose-response curve of EXPAREL, an investigational extended-duration formulation of the local anesthetic bupivacaine, on both motor and sensory block when applied in a fixed volume adjacent to the femoral nerve.

Timeline

Start: 2012-02
Primary completion: 2012-04
Completion: 2012-04

Publications

Background Ilfeld BM, Eisenach JC, Gabriel RA. Clinical Effectiveness of Liposomal Bupivacaine Administered by Infiltration or Peripheral Nerve Block to Treat Postoperative Pain. Anesthesiology. 2021 Feb 1;134(2):283-344. doi: 10.1097/ALN.0000000000003630.
Background Ilfeld BM, Gabriel RA, Eisenach JC. Liposomal Bupivacaine Infiltration for Knee Arthroplasty: Significant Analgesic Benefits or Just a Bunch of Fat? Anesthesiology. 2018 Oct;129(4):623-626. doi: 10.1097/ALN.0000000000002386. No abstract available.
Results Ilfeld BM, Malhotra N, Furnish TJ, Donohue MC, Madison SJ. Liposomal bupivacaine as a single-injection peripheral nerve block: a dose-response study. Anesth Analg. 2013 Nov;117(5):1248-56. doi: 10.1213/ANE.0b013e31829cc6ae.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	SKY0402	Unknown	0 mg	Other
Subject	SKY0402	Unknown	1 mg	Other
Subject	SKY0402	Unknown	2 mg	Other
Subject	SKY0402	Unknown	3 mg	Other

Indications

No indication recorded.