Effects of Administration of Fostamatinib on Blood Concentrations of Digoxin in Healthy Subjects

Phase 1 Completed 21 enrolled AstraZeneca

Non-randomizedSingle-groupOpen-labelBasic science

Summary

The purpose of this study is to investigate the drug interaction between fostamatinib and digoxin by comparing the safety, tolerability and plasma concentration of digoxin when administered alone and with fostamatinib in healthy subjects.

Timeline

Start: 2011-06
Primary completion: 2011-09
Completion: 2011-09

Publications

Martin P, Gillen M, Millson D, Oliver S, Brealey C, Elsby R, Baluom M, Lau D, Mant T. Effects of Fostamatinib on the Pharmacokinetics of Digoxin (a P-Glycoprotein Substrate): Results From in Vitro and Phase I Clinical Studies. Clin Ther. 2015 Dec 1;37(12):2811-22. doi: 10.1016/j.clinthera.2015.09.018. Epub 2015 Oct 26.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Digoxin	Other / unclassified	0.25 mg	Oral
Subject	Fostamatinib	Small molecule	100 mg	Oral

Effects of Administration of Fostamatinib on Blood Concentrations of Digoxin in Healthy Subjects

Summary

Timeline

Publications

Drugs

Indications