Comparing 3 Antibiotic Regimes for Erythema Migrans in General Practice

Phase 4 Completed 225 enrolled Morten Lindbaek Norwegian Institute of Public Health · collab Norwegian University of Life Sciences · collab Sorlandet Hospital HF · collab

RandomizedParallel-groupTriple-blindTreatment

Summary

Tick borne diseases are increasing in Norway. Lyme borreliosis is the most common infection. Erythema migrans is mainly diagnosed and treated in general practice. There is disagreement about what antibiotic treatment that should be given. An RCT with the three most common antibiotics used, will support data for revision of national guidelines.

Timeline

Start: 2011-06
Primary completion: 2013-12
Completion: 2014-12

Publications

Eliassen KE, Reiso H, Berild D, Lindbaek M. Comparison of phenoxymethylpenicillin, amoxicillin, and doxycycline for erythema migrans in general practice. A randomized controlled trial with a 1-year follow-up. Clin Microbiol Infect. 2018 Dec;24(12):1290-1296. doi: 10.1016/j.cmi.2018.02.028. Epub 2018 Mar 2.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Amoxicillin	Other / unclassified	500 mg	—
Comparator	Doxycycline	Small molecule	100 mg	—
Comparator	Penicillin V	Small molecule	1300 mg	—

Comparing 3 Antibiotic Regimes for Erythema Migrans in General Practice

Summary

Timeline

Publications

Drugs

Indications