drugset / Trial / NCT01369017
Effect of Interleukin-1 Receptor Antagonist on Inhalation of 20,000 EU Clinical Ctr Reference Endotoxin in Normal Volunteers
Phase 1
Completed
17 enrolled
Michelle Hernandez, MD
National Institute of Allergy and Infectious Diseases (NIAID) · collab
RandomizedCrossoverDouble-blindBasic science
Summary
The investigators want to see if healthy people who are given 2 doses of a medication called anakinra, which is used to treat moderate to severe rheumatoid arthritis, (RA) and then exposed to a form of air pollution, called Endotoxin, have less inflammation with the medication. Endotoxin is believed to be one of the causes of asthma attacks.
Timeline
- Start
- 2011-10
- Primary completion
- 2013-07
- Completion
- 2013-07
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Anakinra | Protein / enzyme biologic | 1 mg/kg | Subcutaneous |
Indications
No indication recorded.