Carbon Dioxide (Carbogen) for the Treatment of Febrile Seizures

Summary

The aim of this clinical trail is to evaluate the efficacy of a Carbogen inhalation in patients with febrile seizures compared to a placebo-inhalation. Further aims are the evaluation of the safety of the Carbogen inhalation via a low-pressure can with a breathing mask in a home-setting, the manageability of the Carbogen inhalation via a low pressure can with a breathing mask in a home-setting or on the way (mobility), the quality of life of the parents and children using the low pressure can with a breathing mask in a home-setting or on the way (mobility) and the contentment and anxiety of the parents.

Timeline

Start

2012-08

Primary completion

2015-06

Completion

2015-06

Publications

• Background Ohlraun S, Wollersheim T, Weiss C, Martus P, Weber-Carstens S, Schmitz D, Schuelke M. CARbon DIoxide for the treatment of Febrile seizures: rationale, feasibility, and design of the CARDIF-study. J Transl Med. 2013 Jun 27;11:157. doi: 10.1186/1479-5876-11-157.
• Weiss C, Hucko A, Muller-Ohlraun S, Marschenz S, Martus P, Schmitz D, Schuelke M. The use of carbogen for interruption of febrile seizures - the randomized controlled CARDIF trial. PLoS One. 2025 Dec 23;20(12):e0324422. doi: 10.1371/journal.pone.0324422. eCollection 2025.

Drugs

Indications

No indication recorded.