drugset / Trial / NCT01372293
71A/G HSD17B5 SNP and Effects of Oral Contraceptive Pill in PCOS Women
Completed
49 enrolled
Federal University of Rio Grande do Sul
Conselho Nacional de Desenvolvimento Científico e Tecnológico · collabCoordenação de Aperfeiçoamento de Pessoal de Nível Superior. · collabHospital de Clinicas de Porto Alegre · collab
NaSingle-groupOpen-labelTreatment
Summary
An association of the single nucleotide polymorphism (SNP) in the promoter gene that codify for 17b-HSD5 enzyme (71A\>G) with polycystic ovary syndrome (PCOS) and hyperandrogenemia has been suggested in previous studies. Given the role of 17b-HSD5 in androgenic metabolism producing testosterone from precursors, the investigators hypothesis is that women with PCOS and with the variant allele G have a poor response on hirsutism and on hormonal and metabolic variables after oral contraceptive pill (OCP) treatment for 6 months.
Timeline
- Start
- 2005-01
- Primary completion
- 2008-01
- Completion
- 2010-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Gestodene | Small molecule | 75 ug | Oral |
| Subject | ethinyl estradiol | Small molecule | 20 ug | Oral |