Use of N-Acetylcysteine During Liver Procurement

Summary

Randomized prospective study on the impact on the post-LT outcome by the infusion of N-acetylcysteine (NAC) during the liver procurement procedure, as an anti-oxidant agent to reduce the ischemia-reperfusion damage of organs for liver transplantation (LT).

Timeline

Start

2006-12

Primary completion

2009-07

Completion

2009-07

Outcome

Met primary endpoint

paper In conclusion, the NAC harvesting protocol significantly improves graft survival. PMID 22859317 ↗

paper 93% and 90%, respectively, in the NAC group and 82% and 70%, respectively, in the control group (P = 0.02). PMID 22859317 ↗

Publications

• Results D'Amico F, Vitale A, Gringeri E, Valmasoni M, Carraro A, Brolese A, Zanus G, Neri D, Boccagni P, Violi P, Pauletto A, D'Amico FE, D'Amico DF, Cillo U. SYSTEMIC AND LOCO-REGIONAL INFUSION OF N-ACETILCISTEINA DURING LIVER PROCUREMENT: A PROSPECTIVE RANDOMIZED CONTROLLED STUDY (Abstract# 488), The International Liver Transplantation Society: 14th Annual International Congress, July 9-12, 2008, Paris, France. Liver Transplantation, 14: S1-S269. doi: 10.1002/lt.21569
• Results D'Amico F, Vitale A, Piovan D, Bertacco A, Ramirez Morales R, Chiara Frigo A, Bassi D, Bonsignore P, Gringeri E, Valmasoni M, Garbo G, Lodo E, D'Amico FE, Scopelliti M, Carraro A, Gambato M, Brolese A, Zanus G, Neri D, Cillo U. Use of N-acetylcysteine during liver procurement: a prospective randomized controlled study. Liver Transpl. 2013 Feb;19(2):135-44. doi: 10.1002/lt.23527. Epub 2012 Sep 26.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	N-acetylcystein	Unknown	30 mg/kg	Other
Subject	N-acetylcystein	Unknown	150 mg/kg	Other

Indications