Study to Assess the Concentration of Avibactam and Ceftazidime in Epithelial Lining Fluid and Plasma

Phase 1 Completed 45 enrolled Pfizer

Non-randomizedParallel-groupOpen-labelBasic science

Summary

This is an open-label study divided in 2 parts and 3 cohorts to determine the concentration of Avibactam and Ceftazidime in the lining of the lungs and the blood.

Timeline

Start: 2011-08
Primary completion: 2012-07
Completion: 2012-07

Publications

Background Nicolau DP, Siew L, Armstrong J, Li J, Edeki T, Learoyd M, Das S. Phase 1 study assessing the steady-state concentration of ceftazidime and avibactam in plasma and epithelial lining fluid following two dosing regimens. J Antimicrob Chemother. 2015 Oct;70(10):2862-9. doi: 10.1093/jac/dkv170. Epub 2015 Jul 1.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ceftazidime	Small molecule	2000 mg	Intravenous
Subject	Ceftazidime	Small molecule	3000 mg	Intravenous
Subject	avibactam	Small molecule	500 mg	Intravenous
Subject	avibactam	Small molecule	1000 mg	Intravenous

Indications

No indication recorded.