Effects of Gastric pH on the Pharmacokinetics of Dasatinib

Phase 1 Completed 10 enrolled University of California, San Francisco Genentech, Inc. · collab

RandomizedCrossoverOpen-labelBasic science

Summary

The goal of this study is to evaluate the ability of a natural supplement (betaine hydrochloride) to affect the absorption of dasatinib in healthy volunteers. The investigators predict that betaine hydrochloride will increase the absorption of dasatinib, in volunteers pre-treated with proton-pump inhibitors (PPIs).

Timeline

Start: 2011-08
Primary completion: 2014-02
Completion: 2014-02

Publications

Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. doi: 10.1021/mp4003738. Epub 2013 Sep 10.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Betaine	Small molecule	1500 mg	Oral
Subject	dasatinib anhydrous	Small molecule	100 mg	Oral
Background	Rabeprazole	Small molecule	20 mg	Oral

Indications

No indication recorded.