drugset / Trial / NCT01401504
Study of an Investigational Drug, ASP3026, in Patients With Solid Tumors
NaSingle-groupOpen-labelTreatment
Summary
A study to evaluate the safety and anti-tumor activity of ASP3026 in patients with advanced malignancies (solid tumors).
Timeline
- Start
- 2011-05
- Primary completion
- 2014-01
- Completion
- 2014-01
Publications
- Ono A, Murakami H, Seto T, Shimizu T, Watanabe S, Takeshita S, Takeda K, Toyoshima J, Nagase I, Bahceci E, Morishita M, Morita S, Fukuoka M, Nakagawa K. Safety and Antitumor Activity of Repeated ASP3026 Administration in Japanese Patients with Solid Tumors: A Phase I Study. Drugs R D. 2021 Mar;21(1):65-78. doi: 10.1007/s40268-020-00331-2. Epub 2020 Dec 17.
- Ono A, Murakami H, Serizawa M, Wakuda K, Kenmotsu H, Naito T, Taira T, Koh Y, Ohde Y, Nakajima T, Endo M, Takahashi T. Drastic initial response and subsequent response to two ALK inhibitors in a patient with a highly aggressive ALK-rearranged inflammatory myofibroblastic tumor arising in the pleural cavity. Lung Cancer. 2016 Sep;99:151-4. doi: 10.1016/j.lungcan.2016.07.002. Epub 2016 Jul 5.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | ASP3026 | Small molecule | 25 mg | Oral |
| Subject | ASP3026 | Small molecule | 50 mg | Oral |
| Subject | ASP3026 | Small molecule | 75 mg | Oral |
| Subject | ASP3026 | Small molecule | 125 mg | Oral |
| Subject | ASP3026 | Small molecule | 200 mg | Oral |
| Subject | ASP3026 | Small molecule | 325 mg | Oral |