drugset / Trial / NCT01401673
Phase II Open-Label Pilot Study of V3381 in Chronic Cough
Phase 2
Terminated
12 enrolled
Vernalis (R&D) Ltd
Manchester University NHS Foundation Trust · collab
Non-randomizedSingle-groupOpen-labelTreatment
Summary
The investigators hypothesise that cough reflex hypersensitivity, demonstrated in chronic cough patients, is due to a phenomenon known as central sensitisation. Central sensitisation is a hyper-excitability of the sensory nerves as they join the central nervous system, and is believed to be mediated by the N-Methyl-D-Aspartate (NMDA) receptor\[1-3\].
Timeline
- Start
- 2009-10
- Primary completion
- 2010-08
- Completion
- 2010-08
Outcome
Outcome not reported
Stopped: “Lack of efficacy”
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Indantadol | Unknown | — | — |
Indications
No indication recorded.