Tight Hemodynamic Control in Patients Who Are Chronically on Metoprolol

Summary

This study proposes to assess the effect of the standard of care, which is continuation of the pre op beta blocker dose into the post operative period compared to the administration of esmolol titrated to a pre determined target HR. The primary outcome will compare postoperative plasma levels of metoprolol in 2 cohorts in a group who has been continued on metoprolol (administrated via a nasogastric tube in NPO patients) to a group who has been withdrawn from metoprolol but given an esmolol infusion titrated to HR. Secondary outcomes will compare a) the hemodynamic responses, documenting the incidence of unplanned hypotension and bradycardia and b) to compare the effects of Heart rate to the incidence of myocardial ischemia, arrhythmias, delirium and infarction.

Timeline

Start

2011-04

Primary completion

2011-04

Completion

2013-12

Outcome

Outcome not reported

Stopped (Enrollment): “Enrollment slow over 2 years a change in the population less on metoprolol than initially anticipated”

Drugs

Indications