drugset / Trial / NCT01413542
Pharmacogenetics of Ace Inhibitor-Associated Angioedema
RandomizedCrossoverDouble-blindTreatment
Summary
The investigators would like to find out if sitagliptin (dipeptidyl peptidase-4 or DPP4 inhibition), a drug to treat diabetes, affects blood vessel relaxation in healthy people receiving enalapril (angiotensin converting enzyme or ACE inhibition), a blood pressure medicine. Understanding how these drugs interact in healthy people will help us learn their potential effects in people who have diabetes.
Timeline
- Start
- 2011-11
- Primary completion
- 2013-07
- Completion
- 2014-07
Publications
- Devin JK, Pretorius M, Nian H, Yu C, Billings FT 4th, Brown NJ. Dipeptidyl-peptidase 4 inhibition and the vascular effects of glucagon-like peptide-1 and brain natriuretic peptide in the human forearm. J Am Heart Assoc. 2014 Aug 26;3(4):e001075. doi: 10.1161/JAHA.114.001075.
- Devin JK, Pretorius M, Nian H, Yu C, Billings FT 4th, Brown NJ. Substance P increases sympathetic activity during combined angiotensin-converting enzyme and dipeptidyl peptidase-4 inhibition. Hypertension. 2014 May;63(5):951-7. doi: 10.1161/HYPERTENSIONAHA.113.02767. Epub 2014 Feb 10.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Bradykinin | Protein / enzyme biologic | 23.6 unknown | Other |
| Comparator | Bradykinin | Protein / enzyme biologic | 47.2 unknown | Other |
| Comparator | Bradykinin | Protein / enzyme biologic | 94.3 unknown | Other |
| Comparator | ENALAPRILAT ANHYDROUS | Small molecule | 0.33 ug | Other |
| Comparator | GLP-1 | Peptide | 0.45 unknown | Other |
| Comparator | GLP-1 | Peptide | 3.6 unknown | Other |
| Comparator | Sitagliptin | Small molecule | 200 mg | Oral |
| Comparator | Substance P | Small molecule | 2 unknown | Other |
| Comparator | Substance P | Small molecule | 4 unknown | Other |
| Comparator | Substance P | Small molecule | 8 unknown | Other |
| Comparator | brain natriuretic peptide | Peptide | 0.9 unknown | Other |
| Comparator | brain natriuretic peptide | Peptide | 1.8 unknown | Other |
| Comparator | brain natriuretic peptide | Peptide | 3.6 unknown | Other |