Effect of Multiple Dose Levels of SRT2379 on Endotoxin-Induced Inflammation

Summary

SRT2379 is a potent small molecule activator of SIRT1 that has been found to inhibit systemic inflammation induced by intravenous injection of lipopolysaccharide (LPS) in mice. The objective of this study is to determine the effect of a single administration of SRT2379, at multiple-dose levels, on the inflammatory response to low dose endotoxin.

Timeline

Start

2011-08-30

Primary completion

2011-12-12

Completion

2011-12-12

Drugs

Indications