Pharmacodynamics of Mitiglinide/Sitagliptin Compared to Mitiglinide and Sitagliptin

Summary

1. Explore pharmacodynamics * glucose * insulin * C-peptide * glucagon * intact GLP-1 * DPP-4 activity * CGMS (continuous glucose monitoring system) 2. Assess Safety * adverse events * clinical laboratory test * physical examination

Timeline

Start

2010-05

Primary completion

2011-04

Completion

2011-04

Publications

• Jung JA, Kaku K, Kim JH, Kim JR, Ko JW, Lee SY, Huh W. Additive postprandial glucose-lowering effects of mitiglinide and sitagliptin in patients with type 2 diabetes mellitus. Adv Ther. 2013 Nov;30(11):1018-29. doi: 10.1007/s12325-013-0072-x. Epub 2013 Nov 19.

Drugs

Indications